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KMID : 0356919950290040524
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Korean Journal of Anesthesiology
1995 Volume.29 No. 4 p.524 ~ p.530
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A Comparative Study of the Epidural Buprenorphine and Morphine for Post-Cesarean Section Pain Relief
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김승환
박찬흠/송필오/이성호/김인규/신명근
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Abstract
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Buprenorphine is a semisynthetic, highly lipophilic opioid derived from thebaine and it is 30 to 40 times more potent than morphine. This study was performed to compare the clinical effects of epidural buprenorphine on postoperative pain control
with
those of epidural morphine in 150 cesarean deliveries.
They were physical status 1 or 2 by ASA classification and randomly divided into three groups. They were administered morphine 3 mg in group Ⅰ, buprenorph;ine 0.15 mg in group Ⅱand buprenorphine 0.3 mg in group Ⅲas first dose mixed with 0.25%
bupivacaine 10 ml respectively through indwelling epidural catheter at the time of ligation of umbilical cord. Second and third doses were administered with 8 hours intervals, morphine 3 mg with N/S 10 ml was injected in group Ⅰand buprenorphine
0.15
mg with N/S 10 ml was injected in groupⅡandⅢrespectively. Their analgesic effects were evaluated by VAS and severity of side effects was also evaluated.
@ES The Results were as follows:
@EN 1) VAS was significantly increased in group Ⅱcompared to groupⅠandⅢ(p<0.05). There was no significant difference between groupⅠandⅢ.
2) Pruritus was lesser in groupⅡandⅢthan groupⅠ(p<0.05).
3) There was no significant difference in nausea and vomiting.
4) None of patients had respiratory depression.
The authors' findings indicate that epidural administration of buprenorphine of suitable dose may be useful in the treatment of postoperative pain.(Korean J Anesthesiol 1995; 29: 524∼530)
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